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The medicube PDRN 99% Serum delivers a concentrated hit of Polynucleotide — a next-generation repair ingredient — straight to where your skin needs it most. Expect deep, lasting hydration, a firmer feel, and a lit-from-within glow that builds with every use.
PDRN at 99% concentration means no fillers, no fluff — just results you can see and feel.
Most hydrating serums layer in extra fragrance, alcohol, or low-grade fillers. The PDRN 99% Serum keeps it clean — high-concentration actives, a featherlight texture, and results your skin can actually show you.
Based on consumer perception studies conducted by medicube.
After cleansing and toning, dispense 2–3 drops of the PDRN 99% Serum onto your fingertips and press gently into your face and neck until fully absorbed. Follow with your moisturiser to seal in the goodness — morning and evening, every day.
Building confidence with clear answers to your concerns.
For best results, use it twice daily — morning and evening — as part of your regular skincare routine. Consistent use is what drives the firming and brightening results over time.
Yes, the formula is fragrance-free and designed to be gentle on reactive complexions. PDRN is a biocompatible ingredient, meaning it works with your skin rather than against it — but as with any new active, do a patch test first if your skin is especially sensitive.
It has a lightweight, watery-gel texture that absorbs quickly without leaving any stickiness or residue. Your skin feels instantly quenched and smooth, not heavy or greasy.
Absolutely. Apply it as the first serum step after toning — thinnest to thickest is the rule — then follow with any targeted treatments and finish with your moisturiser or SPF during the day.
Most users notice an immediate boost in hydration and a subtle glow from day one. Firming and more pronounced brightening typically become visible around day 14, with the most significant results showing at the four-week mark with daily use.
PDRN, or Polynucleotide, is a DNA-derived ingredient originally used in medical aesthetics for skin regeneration. In skincare, it supports collagen production, accelerates cell turnover, and delivers intensive hydration — making it one of the most talked-about actives in K-beauty right now.
It targets dullness, dehydration, loss of firmness, and uneven skin texture. If your skin looks tired, feels tight, or has lost its bounce, this serum was made for exactly that.
Apply the serum before your SPF. The correct order is: cleanser → toner → serum → moisturiser → SPF. Sunscreen should always be the last step in your morning routine to ensure it forms an even, protective layer over the skin.
Real feedback from real customers.
My skin looked so much more alive after just the first morning I used this — it had that glassy, plump finish I've been chasing for ages. Three weeks in and the fine lines around my eyes are genuinely less noticeable. 🌟
The texture is what sold me — it sinks in within seconds and there's zero tackiness left behind, which is perfect under my sunscreen. My dullness has cleared up significantly and people keep asking what I've changed in my routine.
Really impressed with how hydrated my skin feels throughout the day — I used to get tight, dry patches by midday and those have basically gone. Docking one star only because I wish the bottle had a pump applicator instead of a dropper.
I have oily, acne-prone skin and I was nervous about adding a new serum, but this hasn't caused a single breakout. My skin is smooth, clear, and noticeably more even in tone after about three weeks of using it daily.
The brightening effect crept up on me — I didn't notice it day-to-day, then one morning I looked in the mirror and my complexion was genuinely luminous. This is a permanent fixture in my morning routine now.
Good serum — the hydration is real and I can feel how plump my skin is after applying it. I'd love to see results a bit faster but I know PDRN is a long-game ingredient, so I'm sticking with it.
I've tried so many K-beauty serums and the PDRN concentration in this one genuinely sets it apart — my skin barrier feels stronger and I'm not getting the midday redness I used to experience. Absolutely worth every cent.
Very happy with this purchase — my skin feels softer and looks healthier than it has in a while. The dropper delivers a clean, controlled amount so nothing goes to waste, which I appreciate.
This serum has made my hyperpigmentation so much easier to manage — my dark spots are fading faster now that my skin is properly supported and not fighting dehydration on top of everything else. Genuinely grateful I found it.
I layer this under a heavier moisturiser at night and wake up with the bounciest skin — it literally feels like I've had a facial. The firmness around my jawline has improved more in a month than it did in six months of using my previous serum.
Clean, unfussy formula and the hydration payoff is real — my skin no longer looks tired or flat after a long day. Would love a slightly larger bottle given how much I've come to rely on it.
My eczema-prone skin usually reacts to new serums within days, but this one has been completely calm and soothing from day one. The redness around my nose has settled down and my complexion looks more uniform than it ever has.
There's a subtle, clean scent to it — almost clinical but in a luxurious way — and it layers beautifully with my vitamin C in the morning without pilling. Two weeks in and my skin has a plumpness that honestly makes me want to skip foundation.
