(10) Bestseller

Mary&May Spicule Collagen PDRN Cream

R 429.00
Trending Product!
  • Marine spicules stimulate collagen renewal overnight
  • PDRN repairs damaged skin cells at a cellular level
  • Ceramide + panthenol rebuild the barrier on sensitive skin
  • Fast shipping5–14 days
Shipping information

Free shipping to South Africa within 5 to 14 business days for orders R770 and up. Or, standard shipping to South Africa within 5 to 14 business days for R 80.00. Only applies to orders with an order value less than R770.

Why you'll love it

The Cream That Works While You Sleep

Marine spicules and PDRN — two ingredients borrowed from professional skin clinics — meet French collagen in a single nightly cream. Skin feels noticeably firmer and smoother within a fortnight, without a single needle in sight.

What it does

Clinically Inspired Results at Home

Four powerhouse benefits packed into one luxurious cream.

Spicule Renewal
Micro-fine marine spicules gently resurface skin overnight, leaving it visibly smoother by morning.
PDRN Repair
Polynucleotide complex supports cellular repair, helping to fade post-acne marks and dullness over time.
Collagen Plumping
French hydrolysed collagen plumps fine lines and restores a bouncy, supple texture to the skin.
Barrier Fortification
Ceramide and panthenol lock in moisture and soothe reactive skin so the spicules work without irritation.
How it stacks up

Not Your Average Moisturiser

Most creams sit on the surface. This one delivers clinic-grade actives — marine spicules, PDRN, and French collagen — alongside a barrier-calming base that keeps sensitive skin comfortable throughout.

Beauty Warehouse
Others
Marine spicule collagen stimulation
PDRN cellular repair complex
Suitable for sensitive skin
Ceramide-fortified moisture barrier
Visible firmness within a fortnight
The results speak

Skin That Feels Different From Night One

Based on a self-assessment panel of 200 participants using the cream nightly for four weeks.

  • felt skin was noticeably softer after the first night
  • reported visibly firmer, more elastic skin after two weeks
  • said their skin looked more even-toned and plumped after four weeks
How to use

Apply at Night, Wake Up to Better Skin

After cleansing and toning, smooth a pea-sized amount over your face and neck, avoiding the eye area — the spicules work best with a light press-and-release motion rather than rubbing. Follow with your usual moisturiser if needed, or let the cream absorb on its own for a richer finish.

Questions answered

Your questions, answered

Building confidence with clear answers to your concerns.

How often should I use this cream?

This cream is designed for nightly use. Starting out, you can use it every second night to let your skin adjust to the marine spicules, then move to every night once you're comfortable — usually within the first week or two.

Is it safe for sensitive skin?

Yes — the formula includes ceramide and panthenol specifically to support the skin barrier and reduce irritation while the spicules work. That said, if your skin is very reactive, do a patch test behind your ear for two nights before applying it to your full face.

Will it feel tingly or itchy when I apply it?

A mild tingling or warmth is completely normal when using spicule-based products — it means the micro-crystals are doing their job. The sensation usually settles within a few minutes. If you experience prolonged burning or redness, rinse off and reduce frequency.

Can I layer other serums or actives underneath?

Yes, you can apply your usual hydrating toner or essence first. However, avoid combining this cream with other exfoliating actives — like AHAs, BHAs, or retinol — on the same night, as that may over-sensitise the skin.

When will I start seeing results?

Most people notice smoother texture within the first few nights. More visible improvements in firmness and tone typically show up after a consistent fortnight of nightly use, with the best plumping and brightening results visible after four weeks.

What makes PDRN different from regular skincare ingredients?

PDRN (polynucleotide) is a DNA-derived ingredient originally used in medical-grade skin treatments. It supports the skin's own repair processes at a cellular level, which is why it's particularly effective for post-acne marks, dullness, and loss of elasticity rather than just sitting on the surface like many moisturising agents do.

What skin concerns does this cream address?

It targets fine lines, loss of firmness, dull or uneven skin tone, post-acne marks, and a compromised skin barrier. The marine spicules resurface while the PDRN and collagen work on deeper structural support — so it pulls double duty as both a treatment and a moisturiser.

Do I still need a separate moisturiser on top?

For oily or combination skin, most people find the cream sufficient on its own. If your skin is very dry or you're in a dry indoor environment, you can layer a lightweight moisturiser on top after the cream has absorbed for about five minutes.

(10)

Loved by our customers

Real feedback from real customers.

Lerato M.
Verified

I was sceptical about the tingling at first but by night three my skin already felt different — smoother and almost velvety. Two weeks in and my colleagues started asking what I changed in my routine. 😍

Sophia H.
Verified

The texture is unlike any other cream I've tried — it's rich but absorbs completely without leaving a greasy film. My fine lines around my forehead look noticeably softer and I've only been using it for about a fortnight.

Zinhle N.
Verified

Genuinely impressed by how much plumper my cheeks look. I took away one star only because the tub is quite small for the price, but the results are real so I'll be repurchasing.

Anika V.
Verified

My skin is sensitive and prone to redness, and I was nervous about the spicules — but starting every second night worked perfectly. By week two I was using it nightly with zero irritation and noticeably more even skin tone.

Priya R.
Verified

The mild tingle on application is actually satisfying once you know it's the spicules working. My old acne marks have faded more in a month with this cream than with the vitamin C serum I used for six months.

Tshepo B.
Verified

Didn't think a moisturiser could make a real difference to the firmness of my jaw area but here we are. Still working through the tub so it's early days, but the bounce-back when I press my cheek is clearly improved.

Charlotte D.
Verified

I use it after my toner and before nothing — just the cream on its own — and I wake up to genuinely dewy skin rather than the tightness I usually get. The scent is very faint and clean, which I prefer.

Naledi K.
Verified

Great product overall. The formula feels luxurious and my skin is definitely firmer. My only note is that it's best suited to nighttime use — when I tried it under makeup it pilled slightly, so I stick to evenings now.

Ashika P.
Verified

As a dermatology nurse I was curious about the PDRN claim and I can say the science is legit. My skin has responded beautifully — clearer, firmer, and the rough texture on my chin from old breakouts is almost gone after four weeks.

Marlize S.
Verified

Comfortable enough for my dry, reactive skin which is saying a lot — most active creams leave me flaky or tight by morning. This one kept my skin soft and calm, and the firmness improvement is real even if subtle in the first couple of weeks.