I was sceptical about the tingling at first but by night three my skin already felt different — smoother and almost velvety. Two weeks in and my colleagues started asking what I changed in my routine. 😍
Mary&May Spicule Collagen PDRN Cream
- Marine spicules stimulate collagen renewal overnight
- PDRN repairs damaged skin cells at a cellular level
- Ceramide + panthenol rebuild the barrier on sensitive skin
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Fast shipping5–14 days
Shipping information
Free shipping to South Africa within 5 to 14 business days for orders R770 and up. Or, standard shipping to South Africa within 5 to 14 business days for R 80.00. Only applies to orders with an order value less than R770.
The Cream That Works While You Sleep
Marine spicules and PDRN — two ingredients borrowed from professional skin clinics — meet French collagen in a single nightly cream. Skin feels noticeably firmer and smoother within a fortnight, without a single needle in sight.
Clinically Inspired Results at Home
Four powerhouse benefits packed into one luxurious cream.
Not Your Average Moisturiser
Most creams sit on the surface. This one delivers clinic-grade actives — marine spicules, PDRN, and French collagen — alongside a barrier-calming base that keeps sensitive skin comfortable throughout.
Skin That Feels Different From Night One
Based on a self-assessment panel of 200 participants using the cream nightly for four weeks.
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97%felt skin was noticeably softer after the first night
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95%reported visibly firmer, more elastic skin after two weeks
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96%said their skin looked more even-toned and plumped after four weeks
Apply at Night, Wake Up to Better Skin
After cleansing and toning, smooth a pea-sized amount over your face and neck, avoiding the eye area — the spicules work best with a light press-and-release motion rather than rubbing. Follow with your usual moisturiser if needed, or let the cream absorb on its own for a richer finish.
Your questions, answered
Building confidence with clear answers to your concerns.
How often should I use this cream?
This cream is designed for nightly use. Starting out, you can use it every second night to let your skin adjust to the marine spicules, then move to every night once you're comfortable — usually within the first week or two.
Is it safe for sensitive skin?
Yes — the formula includes ceramide and panthenol specifically to support the skin barrier and reduce irritation while the spicules work. That said, if your skin is very reactive, do a patch test behind your ear for two nights before applying it to your full face.
Will it feel tingly or itchy when I apply it?
A mild tingling or warmth is completely normal when using spicule-based products — it means the micro-crystals are doing their job. The sensation usually settles within a few minutes. If you experience prolonged burning or redness, rinse off and reduce frequency.
Can I layer other serums or actives underneath?
Yes, you can apply your usual hydrating toner or essence first. However, avoid combining this cream with other exfoliating actives — like AHAs, BHAs, or retinol — on the same night, as that may over-sensitise the skin.
When will I start seeing results?
Most people notice smoother texture within the first few nights. More visible improvements in firmness and tone typically show up after a consistent fortnight of nightly use, with the best plumping and brightening results visible after four weeks.
What makes PDRN different from regular skincare ingredients?
PDRN (polynucleotide) is a DNA-derived ingredient originally used in medical-grade skin treatments. It supports the skin's own repair processes at a cellular level, which is why it's particularly effective for post-acne marks, dullness, and loss of elasticity rather than just sitting on the surface like many moisturising agents do.
What skin concerns does this cream address?
It targets fine lines, loss of firmness, dull or uneven skin tone, post-acne marks, and a compromised skin barrier. The marine spicules resurface while the PDRN and collagen work on deeper structural support — so it pulls double duty as both a treatment and a moisturiser.
Do I still need a separate moisturiser on top?
For oily or combination skin, most people find the cream sufficient on its own. If your skin is very dry or you're in a dry indoor environment, you can layer a lightweight moisturiser on top after the cream has absorbed for about five minutes.
Loved by our customers
Real feedback from real customers.
The texture is unlike any other cream I've tried — it's rich but absorbs completely without leaving a greasy film. My fine lines around my forehead look noticeably softer and I've only been using it for about a fortnight.
Genuinely impressed by how much plumper my cheeks look. I took away one star only because the tub is quite small for the price, but the results are real so I'll be repurchasing.
My skin is sensitive and prone to redness, and I was nervous about the spicules — but starting every second night worked perfectly. By week two I was using it nightly with zero irritation and noticeably more even skin tone.
The mild tingle on application is actually satisfying once you know it's the spicules working. My old acne marks have faded more in a month with this cream than with the vitamin C serum I used for six months.
Didn't think a moisturiser could make a real difference to the firmness of my jaw area but here we are. Still working through the tub so it's early days, but the bounce-back when I press my cheek is clearly improved.
I use it after my toner and before nothing — just the cream on its own — and I wake up to genuinely dewy skin rather than the tightness I usually get. The scent is very faint and clean, which I prefer.
Great product overall. The formula feels luxurious and my skin is definitely firmer. My only note is that it's best suited to nighttime use — when I tried it under makeup it pilled slightly, so I stick to evenings now.
As a dermatology nurse I was curious about the PDRN claim and I can say the science is legit. My skin has responded beautifully — clearer, firmer, and the rough texture on my chin from old breakouts is almost gone after four weeks.
Comfortable enough for my dry, reactive skin which is saying a lot — most active creams leave me flaky or tight by morning. This one kept my skin soft and calm, and the firmness improvement is real even if subtle in the first couple of weeks.



